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Orexin is a 'master controller' of the sleep wake control system. It stimulates the wake-promoting system and stabilises the switching between wake and sleep.
Narcolepsy is often poorly understood, which can lead to difficulties and delays making the diagnosis. Treatments are often partially effective, so people with narcolepsy will usually have ongoing symptoms that impact on their daily life and need understanding and support of family, friends, employers and health professionals to function at their best.